Plasma Exchange
Category I
Standard and acceptable under certain circumstances, Including primary therapy
Coagulation factor inhibitors Leukemia with hyperleukocytosis syndrome
Cryoglobulinemia Sickle cell syndromes (also see Category II)
Goodpasture's syndrome Thrombocytosis , symptomatic
Guillain-Barre syndrome
Homozygous familial hypercholesterolemia
Hyperviscosity syndrome
Myasthenia gravis
Posttransfusion purpura
Refsum's disease
Thrombotic thrombocytopenic purpura (TTP)
Category II
Sufficient evidence to suggest efficacy ; acceptable therapy on an adjunctive basis
Chronic inflammatory demyelinating polyneuropathy Cutaneous T-cell Lymphoma (cytoreduction or photopheresis)
Cold agglutinin disease  
Drug overdose and poisoning (protein bound toxins) Hairy cell leukemia
Hemolytic uremic syndrome (HUS) Hyperparasitemia (e.g., malaria)
Pemphigus vularis Peripheral blood stem cell collections for hematopoietic reconstitution
Rapidly progressive glomerulonephritis  
Systemic Vasculitis (1o or 2 o RA or SLE) Rheumatoid arthritis
Category III
Inconclusive evidence for efficacy; uncertain benefit/risk ratio
ABO-incompatible organ or marrow transplantation Life threatening hemolytic transfusion reactions Multiple sclerosis
Maternal treatment of maternal-fetal incompatibility (HDN) Multiple sclerosis
Thyroid storm Organ transplant rejection (also photopheresis)
Multiple sclerosis Sickle cell disease (prophylactic use in pregnancy)
Progressive systemic sclerosis
Pure red cell aplasia
Transfusion refractoriness due to alloantibodies (red cell , platelet , HLA )
Warm autoimmune hemolytic anemia
Category IV
Lack of efficancy in controlled trials
AIDS (for symptoms of immunodeficiency) Leukemia with out hyperleukocytosis syndromes
Amyotrophic lateral sclerosis Hypereosinophilia
Aplastic anemia Polymyositis/dermatomyositis
Fulminant hepatic failure
ITP (chronic)
Lupus nephritis
Renal transplant rejection
Rheumatoid arthritis



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